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HemaSeq Human 248 Gene Mutation Detection Kit（NGS-for Illumina）

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HemaSeq Human 74 Gene Mutation Detection Kit （NGS-for Illumina）

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Whole Exome Sequencing Detection Kit (RTS)

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HemaSeq Human 149 Gene Mutation Detection Kit （NGS-for Illumina）

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HemaSeq Human 260 Gene Mutation Detection Kit （NGS-for Illumina）

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HemaSeq人类248基因突变检测试剂盒（可逆末端终止测序法）-Part F_3504x2613

HemaSeq人类248基因突变检测试剂盒（可逆末端终止测序法）-Part A_3504x2613

HemaSeq人类248基因突变检测试剂盒（可逆末端终止测序法）-Part B_3504x2613

HemaSeq人类248基因突变检测试剂盒（可逆末端终止测序法）-Part C_3504x2613

HemaSeq人类248基因突变检测试剂盒（可逆末端终止测序法）-Part D_3504x2613

HemaSeq人类248基因突变检测试剂盒（可逆末端终止测序法）-Part E_3504x2613

HemaSeq Human 248 Gene Mutation Detection Kit（NGS-for Illumina）

Product introduction Targeted-capture NGS technology is applied to detect 248 core genes related to myeloid hematological tumors (MPN/AML/MDS/CMML) simultaneously. SNV, Indel and splicing can be obtained in the 248 core target regions at one time.

Inquiry

Cat. No.:

S0918-S

Spec:

6 rxns/Kit（60 Tests）

Product description

Parameters

Target Population:

Patients with suspected or confirmed myeloid hematological tumors such as AML, MDS, MPN, CMML, JMML.

Detection Range:

Related disease	Number of genes	Actionable results
MDS	118	Diagnosis typing Prognosis judgment Guiding therapy MRD testing Clonal evolution
MDS/MPN	41
MPN	78
AML	186
Genetic susceptibility	49

Advantages

1. Based on authoritative databases, professional guidelines, and the latest literature, it covers both common gene mutations used for clinical detection, and disease-related genes for clinical research as reported in the literature.

2. Targeted capturing probe design enables the detection of all point mutations and small fragment insertions/deletions in the CDS region.

3. The probe coverage reaches 99.3%, with a capture region of 1.02 M, suitable for deep sequencing and meeting clinical needs of 2000× detection.

Clinical Significance of Genes:

Clinical application	Gene example
Diagnosis and differential diagnosis	ANKRD26,APC,ASXL1,ATG2B,BCL10,BRCA1,BRCA2,CALR,CBL,CD95,CEBPA, CHEK2,CSF3R,DDX41,DNMT3A,EPCAM,ERBB3,ETNK1,ETV6,EZH2,FANCA,FA NCB,FANCC,FANCD2,FANCE,FANCF,FANCG,FANCI,FANCL,FANCM,GATA2.GS KIP，IDH1，IDH2，IKZF2，IKZF3.
Prognosis evaluation	ABL1,ASXL1,ASXL2,ATM,BCL10,BCOR,BLM,BRCC3,CCND3,CDKN2A,CEBPA，DNMT3A，ETV6，EZH2，FBXW7，FGFR3，FLT3，FOXP1.
Guiding therapy	ABL1,ALK,BCL2,BCR,BRAF,CSF3R,FGFR3,FLT3,HRAS,IDHI,IDH2,JAK1,J AK2，JAK3，KIT，KRAS，MDM2，MET，MPL，NF1，NPM1.
Clinical research	ACTB,AF1O,ANKRD26,ARID1A,ARID1B,ARID2,ASXL3,ATRX,BAP1,BCL11 B,BCL3,BCL7A,BCR,BRD4,BTG1,CAD,CBFB,CBLB.CDKN1B,CHD2,CIITA, CMYA5,COL1A1,CPS1.CSMD1,CTCF,CUX1,DHX15,DICER1,DOT1L,DTX1,E BF1，EED，EGR1.

Gene List (only partial genes displayed)

ABL1	KIT	NFE2	PTPN11	GATA2	KRAS
ANKRD26	CSF3R	NOTCH1	RAD21	GNAS	SF1
ASXL1	CSMD1	NPM1	ROBO1	IDH1	SF3A1
ATM	CUX1	NRAS	ROBO2	IDH2	SF3B1
BCOR	DDX41	PDGFRA	RUNX1	IKZF1	SMC1A
BCORL1	DNMT3A	PHF6	SETBP1	JAK1	SMC3
BRAF	EP300	PIGA	ETV6	JAK2	SRP72
CALR	ETNK1	PRPF40B	EZH2	JAK3	SRSF2
CBL	MPL	PRPF8	FLT3	KMT2C	STAG2
CEBPA	NF1	PTEN	GATA1	KMT2D	SUZ12

Ordering Information

Cat. No.

Product

Strength

S0918-S

HemaSeq Human 248 Gene Mutation Detection Kit
（NGS-for Illumina）

6 rxns/Kit

（60 Tests）

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None

HemaSeq Human 74 Gene Mutation Detection Kit （NGS-for Illumina）

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HemaSeq Human 248 Gene Mutation Detection Kit（NGS-for Illumina）