Products
HemaSeq Human 93 Gene Mutation Detection Kit （NGS-for Illumina）
Cat. No.:
S0842-S
Spec:
6 rxns/Kit（60 Tests）
Product description
Parameters
Detection Content
NGS technology allows for the detection of mutations in 93 gene associated with small B-cell lymphoma in a single test. These genes (excluding IGHV) can provide auxiliary diagnosis, differential diagnosis, prognosis and treatment of CLL/SLL.
Advantages
1. Covers related genes on various signaling pathways of pathogenesis and key genes in WHO, NCCN, guidelines of Chinese Society of Clinical Oncology (CSCO) lymphoid malignancies, Chinese guidelines for diagnosis and treatment of small B-cell lymphoma subtypes, expert consensuses and authoritative literature to assist clinical decision-making and meet scientific research needs.
2. Covers library preparation reagents, hybrid capture reagents, and probes for 93 genes in Kit components (including complete exonic regions of all genes).
3. Flexible with Illumina and ThermoFisher sequencing platforms.
4. High sensitivity, with accurate and stable detection of 1% mutation frequency.
Specimen Requirements
1、Bone marrow/Peripheral blood
2–3 mL bone marrow or peripheral blood (bone marrow preferred), with > 5% tumor cells infiltrating into the blood, and WBC count > 5*109/L; increase sample volume (> 5 mL) when insufficient.
2、DNA
The total DNA amount should be > 1 μg, OD260/280 should be within 1.8–2.0, with a concentration > 30 ng/μL, and the agarose gel electrophoresis band should be > 20 kb.
3、Cell lines
WBC count > 15*106; total amount of extractable DNA > 1 μg.
Target Population
To meet the clinical needs of chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL), a CLL-related gene mutation detection panel has been designed specifically for clinical use. The design of this panel is informed by the NCCN guidelines, WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues (2008 and 2016 revisions), guidelines of the Chinese Society of Clinical Oncology (CSCO) for lymphoid malignancies, Chinese guidelines for diagnosis and treatment of small B-cell lymphoma subtypes, expert consensuses, authoritative classics, and the latest literature, ensuring that it is tailored to the actual clinical needs of practitioners. It's applicable to the prognosis, diagnosis and treatment of CLL/SLL patients. At the same time, this panel also involves main driver genes of common small B-cell lymphoma (WM, MZL, HCL, MCL and FL) that can be used for the differential diagnosis of related diseases.
Gene List (only partial genes displayed)
|
ARID1A |
BMI1 |
CDKN2A |
FAT1 |
KDM6A |
MAPK1 |
|
ARID1B |
BRAF |
CDKN2B |
FBXW7 |
KLF2 |
MED12 |
|
ARID2 |
BTK |
CHD2 |
FPGT |
KLHL6 |
MEF2B |
|
ATM |
CARD11 |
CREBBP |
GRIN2A |
KMT2A |
MGA |
|
ATP6AP1 |
CCND1 |
CXCR4 |
HIST1H1E |
KMT2C |
MIR17HG |
|
ATP6V1B2 |
CCND3 |
DDX3X |
HNRNPH1 |
KMT2D |
MYBBP1A |
|
B2M |
CD38 |
EGR2 |
IDH1 |
KRAS |
MYC |
|
BCL2 |
ITGA4 |
EP300 |
IKZF3 |
LRP1B |
MYCN |
|
BCOR |
CD79B |
EZH2 |
IRF4 |
MAP2K1 |
MYD88 |
|
BIRC3 |
CDKN1B |
FAS |
JAK2 |
MAP3K14 |
NFKBIE |
Ordering Information
| Cat. No. | Product | Strength |
| S0842-S | HemaSeq Human 93 Gene Mutation Detection Kit （NGS-for Illumina） |
6 rxns/Kit （60 Tests） |
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