Products
HemaSeq Human 254 Gene Mutation Detection Kit (NGS-for Illumina)
Cat. No.:
S0963-S
Spec:
6 rxns/Kit (60 Tests)
Product description
Parameters
Detection Content
NGS technology enables the detection of 254 gene mutations of MM at once, including core genes related to disease occurrence, clonal evolution, prognosis evaluation, therapeutic medication, etc., and the genes can be used for MRD monitoring. (see the gene list for details)
Advantages
1、Based on authoritative databases (COSMIC, NCCN, MY CANCER GENOME, PHARMGKB, etc.), professional guidelines (WHO, NCCN, guidelines for the diagnosis and management of multiple myeloma in China, etc.) and the latest literature, it covers both common MM gene mutations used for clinical detection, and disease-related genes for clinical research as reported in the literature.
2、Capture probes designed for the target region: all point mutations, small fragment insertions/deletions in the CDS region of 243 genes, and 11 SNP sites associated with chemotherapeutic agents in the gene.
(1) Covers the hotspot genes related to MM clonal evolution, risk stratification, and targeted therapy.
(2) The probe coverage reaches 99.9%, with a capture region of 1 M, suitable for deep sequencing and meeting clinical needs of 2000× detection.
High sensitivity, with accurate and stable detection of more than 1% mutations.
Specimen Requirements
Sample type: Bone marrow: 3–5 ML, tube (purple cap).
Target Population
Disease screening: include newly diagnosed MM patients at various stages (including MGUS, sMM, MM, PCL, etc.).
Newly diagnosed MM patients: determine genetic risk, assist patient prognosis, and select appropriate treatment regimens.
Relapsed MM patients: indicate clonal evolution, and determine the type and characteristics of disease progression; conduct MRD monitoring.
MM patients with drug resistance: detect resistance-associated mutations and select appropriate treatment and medication regimens.
Gene List (only partial genes displayed)
|
ABCF1 |
ARID1B |
BCL2 |
BRCA2 |
CCNE1 |
CDKN2B |
|
ABI3BP |
ARID2 |
BCL2L11 |
BRWD3 |
CD38 |
CDKN2C |
|
ACTG1 |
ASXL1 |
BCL7A |
BTG1 |
CD74 |
CEP72 |
|
ADAMTS9 |
ATF6 |
BHLHE41 |
C8orf34 |
CDK12 |
CHEK2 |
|
AKT1 |
ATG3 |
BIRC2 |
CARD11 |
CDK2 |
CIC |
|
AKT2 |
ATM |
BIRC3 |
CBFB |
CDK4 |
CKS1B |
|
AKT3 |
ATR |
BLM |
CCNA1 |
CDK6 |
CNOT3 |
|
ALK |
ATRX |
BMPR1A |
CCND1 |
CDK7 |
CRBN |
|
ANK2 |
B2M |
BRAF |
CCND2 |
CDKN1B |
CREBBP |
|
ARID1A |
BAX |
BRCA1 |
CCND3 |
CDKN2A |
CTLA4 |
Ordering Information
| Cat. No. | Product | Strength |
|
S0963-S |
HemaSeq Human 254 Gene Mutation Detection Kit
|
6 rxns/Kit （60 Tests） |
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